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Idase (MAO) inhibitor is contraindicated. At least 14 days should elapse between discontinuation of an MAO inhibitor and initiation of treatment with ZYBAN. ZYBAN is contraindicated in patients who have shown an allergic response to bupropion or the other ingredients that make up ZYBAN. WARNINGS Patients should be made aware that ZYBAN contains the same active ingredient found in WELLBUTRIN and WELLBUTRIN SR used to treat depression, and that ZYBAN should not be used in combination with WELLBUTRIN, WELLBUTRIN SR, or any other medications that contain bupropion. Because the use of bupropion is associated with a dose-dependent risk of seizures, clinicians should not prescribe doses over 300 mg day for smoking cessation. The risk of seizures is also related to patient factors, clinical situation, and concurrent medications, which must be considered in selection of patients for therapy with ZYBAN. ZYBAN should be discontinued and not restarted in patients who experience a seizure while on treatment. • Dose: For smoking cessation, doses above 300 mg day should not be used. The seizure rate associated with doses of sustained-release bupropion up to 300 mg day is approximately 0.1% (1 1,000). This incidence was prospectively determined during an 8-week treatment exposure in approximately 3,100 depressed patients. Data for the immediate-release formulation of bupropion revealed a seizure incidence of approximately 0.4% (4 1,000) in depressed patients treated at doses in a range of 300 to 450 mg day. In addition, the estimated seizure incidence increases almost tenfold between 450 a zyban


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R she experiences any of these symptoms: new or worsening depression; thinking about harming or killing him- or herself or planning or trying to do so; extreme worry; agitation; panic attacks; difficulty falling or staying asleep; irritability; aggressive behavior; acting without thinking; severe restlessness; frenzied, abnormal excitement; or any other sudden or unusual changes in behavior.Your child’s doctor will want to see your child often while he or she is taking bupropion, especially at the beginning of his or her treatment .Your child’s doctor may also want to speak with you or your child by telephone from time to time. Be sure that your child keeps all appointments for office visits or telephone conversations with his or her doctor.Your child's doctor or pharmacist will give you the manufacturer’s patient information sheet (Medication Guide) when your child begins treatment with bupropion. Read the information carefully and ask your child's doctor or pharmacist if you ha

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